Big Bear Bio Consolidated its Operations in Bay Area

September 11, 2001 — Big Bear Bio, Inc. ("Company") consolidated its administrative and research operations in San Francisco Bay Area as of September 2001. The Company has closed its administrative office in Austin, TX and opened new headquarters in Alameda, CA. With its existing research facility in Alameda, Company is integrating its R&D functions by this relocation and consolidation.

The major factor that drove the Company toward this direction was recent significant progress in its product development activities. For majority of its six novel therapeutic product candidates, Company has reached the stage that GMP manufacturing can be prepared. It requires more process management and quality control tasks to the Company's product development team and closer communications between research and development staff. Further, Company needs to hire more skilled staff that wish to involve in product development of its innovative molecules. It is believed that this consolidation of the operation in San Francisco Bay Area will allow the Company to accelerate its corporate and product developments further.

Big Bear Bio, Inc. is a product-oriented biopharmaceutical company that currently possesses six therapeutic product candidates: Phosphatonin (PTN) is a human endogenous polypeptide hormone that reduces serum phosphate levels to treat hyperphosphatemia in renal failure; Rickenon (RKN) is also a human endogenous polypeptide hormone that prevents excessive phosphate loss to treat various disorders including rickets, kidney transplantation, pediatric phosphate loss, etc.; Ossomar (OSM) is a new class of synthetic orally available bone anabolic agent for treatment of osteoporosis; AC-100 (DTN) is a human derived small peptide with very potent and selective bone and dental cell expansion activities that is expected to be used for dental and severe orthopedic disorders; Leukocyte Immobilizing Peptide (LIP) is a synthetic oligopeptide that controls inflammation to treat eczema, GVHD, IBD, RA, etc.; MET-1000 (MET) is a chemically modified peptide that significantly suppresses cancer metastasis. More details are on the Company's website at www.bigbearbio.com.

The Company welcomes the talents in Bay Area who wish to contribute on the development of these unique molecules that should benefit patients significantly.

Headquarters

1070 Marina Village Pkwy., Suite 203
Alameda, CA 94501, USA
Tel: 510-521-5610
Fax: 510-749-7523

Laboratories

851 West Midway Ave., Building 7
Alameda, CA 94501-5085, USA
Tel: 510-749-6760
Fax: 510-749-6767